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A review of the incidence and survival of childhood and adolescent cancer and the effects of treatment on future fertility and endocrine development
Abstract
Cancer is not uncommon in children. The reproductive system is an important site for late effects of cancer treatment, and normal pubertal development depends on an undamaged hypothalamic-pituitary-gonadal axis. Fertility compromise can occur due to chemotherapy, radiotherapy to the hypothalamic-pituitary-gonadal axis, or surgery. Cryopreservation techniques of germ cells are improving and may offer hope for fertility preservation.
Authors' affiliations
M H Botha, Unit for Gynaecological Oncology, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, Western Cape
T F Kruger, Unit for Reproductive Biology, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, Western Cape
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Keywords
Adolescent cancer; fertility preservation; cancer treatment; childhood cancer
Cite this article
South African Journal of Obstetrics and Gynaecology 2012;18(2):48-53.
Article History
Date submitted: 2011-08-31
Date published: 2012-03-29
Date published: 2012-03-29
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