Research

Gestational Outcomes of Patients with Multiple Sclerosis; A Tertiary Center Experience

Ozgur Ozyuncu, Atakan Tanacan, Fatih Aktoz, Melek Buyukeren, Rana Karabudak, Mehmet Sinan Beksac

Abstract


Background and Aim: To demonstrate  impact of multiple sclerosis (MS) on pregnancy outcome.

 Methods: We retrospectively evaluated  demographic features, clinical characteristics, and obstetric outcomes of 47 pregnancies in 24 patients with MS between January 2007 and December 2016.

Results: Patients were divided into three groups: 1) 35 pregnancies in patients with MS who were in remission at the beginning of pregnancy, 2) 10 pregnancies in patients with MS whose disease exacerbated at the beginning of pregnancy, and 3) 2 pregnancies in patients with active MS whose symptoms were relieved after getting pregnant. The overall early pregnancy loss rate was 36.2%, whereas it was 60% and 31.4% in exacerbation and remission groups respectively. On the other hand, the overall preterm delivery rate was 30%. Preterm delivery rate was 29.1% and 50% in  remission and exacerbation groups respectively.

Conclusion: Miscarriage and preterm delivery seem to be important obstetric complications in pregnant women with MS.


Authors' affiliations

Ozgur Ozyuncu, Hacettepe University, Department of Obstetrics and Gynecology, division of Perinatology

Atakan Tanacan, Hacettepe University, Department of Obstetrics and Gynecology, division of Perinatology

Fatih Aktoz, Hacettepe University, Department of Obstetrics and Gynecology, division of Perinatology

Melek Buyukeren, Hacettepe University, Department of Pediatrics, division of Neonatology

Rana Karabudak, Department of Neurology, Hacettepe University, Ankara, Turkey

Mehmet Sinan Beksac, Hacettepe University, Department of Obstetrics and Gynecology, division of Perinatology

Full Text

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Keywords

Pregnancy, Multiple Sclerosis, Antenatal Care

Cite this article

South African Journal of Obstetrics and Gynaecology 2018;24(3):. DOI:10.7196/sajog.1368

Article History

Date submitted: 2018-06-28
Date published: 2019-02-22

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